Treatments for childhood nodular lymphocyte-predominant Hodgkin lymphoma
The following are treatment options for childhood nodular lymphocyte-predominant Hodgkin lymphoma (HL). The healthcare team will suggest treatments based on your child’s needs and work with you to develop a treatment plan. Treatments are based on the stage of the cancer.
Treatments for stage 1 @(Model.HeadingTag)>
Surgery to remove the lymph nodes is the main treatment for stage 1 nodular lymphocyte-predominant childhood HL when doctors think the tumour can be completely removed (resected). The surgeon removes only the lymph nodes that are known to have cancer. After surgery, the healthcare team will follow the child closely for signs that the cancer has come back (recurred).
Surgery to remove the lymph nodes is also called lymph node dissection. Find out more about lymph node dissection.
Treatments for all other stages @(Model.HeadingTag)>
The following treatments may be offered for stage 2, 3 or 4 nodular lymphocyte-predominant childhood HL.
Chemotherapy is the primary treatment for stages 2, 3 and 4 of nodular lymphocyte-predominant childhood HL. It may be given alone or it may be followed by radiation therapy.
Chemotherapy combinations used include:
- COPP/ABV – cyclophosphamide (Procytox), vincristine (Oncovin), prednisone, procarbazine hydrochloride (Matulane) with doxorubicin (Adriamycin), bleomycin (Blenoxane) and vinblastine
- CPV – cyclophosphamide, vinblastine and prednisolone
- DBVE – doxorubicin, bleomycin, vincristine and etoposide (Vepesid, VP-16)
- VAMP – vincristine, doxorubicin, methotrexate and prednisone
- AV-PC – doxorubicin, vincristine, prednisone and cyclophosphamide
Find out more about chemotherapy for childhood Hodgkin lymphoma.
Radiation therapy @(Model.HeadingTag)>
After chemotherapy, low-dose radiation therapy may be given to areas that have cancer. The type of radiation therapy used is external radiation therapy. During external radiation therapy, a machine directs radiation through the skin to the tumour and some of the tissue around it. The dose of radiation and the area treated are kept as small as possible.
Find out more about radiation therapy for childhood Hodgkin lymphoma.
Clinical trials @(Model.HeadingTag)>
Children with cancer may be treated in a clinical trial. Clinical trials look at new ways to prevent, find and treat cancer. Find out more about clinical trials.
Expert review and references
American Cancer Society. Hodgkin Disease. Atlanta, GA: American Cancer Society; 2013.
Lona Roll . Hodgkin Disease. Baggott C, Fochtman D, Foley GV & Patterson Kelly, K (eds.). Nursing Care of Children and Adolsecents with Cancer and Blood Disorders. 4th ed. APHON; 2011: 28:pp.. 1013-1022.
Hodgkin lymphoma in children. Macmillan Cancer Support. Macmillan Cancer Support. London, UK: Macmillan Cancer Support; 2012.
Metzger M, et al . Hodgkin lymphoma. Pizzo, P. A. & Poplack, D. G. (Eds.). Principles and Practice of Pediatric Oncology. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2011: 22:pp. 638-662.
National Cancer Institute. Childhood Hodgkin Cancer Treatment (PDQ®) Patient Version. 2018.
National Cancer Institute. Childhood Hodgkin Lymphoma Treatment (PDQ®) Health Professional Version. 2018: http://www.cancer.gov/.