Chemotherapy for testicular cancer

Chemotherapy uses anticancer (cytotoxic) drugs to destroy cancer cells. It is sometimes used to treat testicular cancer. Your healthcare team will consider your personal needs to plan the drugs, doses and schedules of chemotherapy. You may also receive other treatments.

Chemotherapy is given for different reasons. You may have chemotherapy to:

  • destroy cancer cells in the body
  • destroy cancer cells left behind after surgery and reduce the risk that the cancer will come back (relapse) (called adjuvant chemotherapy)
  • treat cancer that comes back after treatments
  • relieve pain or control the symptoms of advanced testicular cancer (called palliative chemotherapy)

Chemotherapy is usually a systemic therapy. This means that the drugs travel through the blood to reach and destroy cancer cells all over the body, including those that may have broken away from the original tumour in the testicle.

Chemotherapy drugs commonly used for testicular cancer

The following drugs and drug combinations may be used in chemotherapy for testicular cancer.

Standard-dose chemotherapy

The most common chemotherapy combinations used to treat testicular cancer are:

  • BEP – bleomycin, etoposide (Vepesid) and cisplatin
  • EP – etoposide and cisplatin
  • VIP – etoposide, ifosfamide (Ifex) and cisplatin

EP and VIP are used when bleomycin affects the lungs (called pulmonary toxicity) or there is a high risk that it will cause lung damage.

In rare cases, carboplatin may be offered instead of radiation therapy or active surveillance after a radical inguinal orchiectomy (an orchiectomy) for stage 1 seminomas.

If testicular cancer doesn’t respond to drugs in earlier treatments or if the cancer comes back, you may be given another chemotherapy combination (called salvage chemotherapy). You may be offered one of the following combinations:

  • TIP – paclitaxel, ifosfamide and cisplatin
  • VIP – etoposide, ifosfamide and cisplatin
  • VeIP – vinblastine, ifosfamide and cisplatin

Almost all chemotherapy for testicular cancer is given through a needle into a vein (intravenously).

Medicine to help prevent blood clots or infections may also be given along with chemotherapy.

High-dose chemotherapy and stem cell transplant

High-dose chemotherapy with carboplatin and etoposide may be used if testicular cancer comes back after it is treated with standard-dose chemotherapy. After high-dose chemotherapy, a stem cell transplant is done to replace the stem cells that are damaged or destroyed by high-dose chemotherapy. The stem cell transplant uses stem cells from your own blood (called autologous peripheral blood stem cell transplant). The stem cells are collected from your blood before high-dose chemotherapy.

Palliative chemotherapy

Palliative chemotherapy is given to relieve symptoms and extend your life, rather than to treat the cancer itself. Gemcitabine may be given with oxaliplatin, paclitaxel or both as palliative treatment for seminomas or non-seminomas. Etoposide taken by mouth (orally) is also an option for palliative chemotherapy.

Side effects

Side effects can happen with any type of treatment for testicular cancer, but everyone’s experience is different. Some men have many side effects. Others have few or none at all. Your oncologist will discuss possible side effects in great detail with you.

Chemotherapy may cause side effects because it can damage healthy cells as it kills cancer cells. If you develop side effects, they can happen any time during, immediately after or a few days or weeks after chemotherapy. Sometimes late side effects develop months or years after chemotherapy. Most side effects go away on their own or can be treated, but some side effects may last a long time or become permanent.

Side effects of chemotherapy will depend mainly on the type of drug, the dose, how it’s given and your overall health. Some common side effects of chemotherapy drugs used for testicular cancer are:

Tell your healthcare team if you have these side effects or others you think might be from chemotherapy. The sooner you tell them of any problems, the sooner they can suggest ways to help you deal with them.

Information about specific cancer drugs

Details on specific drugs change regularly. Find out more about sources of drug information and where to get details on specific drugs.

Questions to ask about chemotherapy

Find out more about chemotherapy and side effects of chemotherapy. To make the decisions that are right for you, ask your healthcare team questions about chemotherapy.

Expert review and references

  • Guideline Resource Unit (GURU). Testicular Germ Cell Tumours. Edmonton: Alberta Health Services; 2023: Clinical Practice Guideline GU-001 Version: 9.
  • American Cancer Society . High-Dose Chemotherapy and Stem Cell Transplant for Testicular Cancer . 2018 :
  • American Cancer Society . Chemotherapy for Testicular Cancer . 2018 :
  • Hamilton RJ, Canil C, Shrem NS, et al. Canadian Urological Association consensus guidelines: Management of testicular germ cell cancer. Canadian Urological Association Journal. 2022: 16(6):155–173.
  • American Society of Clinical Oncology . Testicular Cancer: Treatment Options . 2017 :
  • National Comprehensive Cancer Network . NCCN Clinical Practice Guidelines in Oncology: Testicular Cancer (Version 2.2018) .
  • Pagliaro LC and Logothetis CJ . Cancer of the testis. DeVita VT Jr, Lawrence TS, & Rosenberg SA. Cancer: Principles & Practice of Oncology. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2015: 70:988-1004.
  • Wood L, Kollmannsberger C, Jewett M, et al . Canadian consensus guidelines for the management of testicular germ cell cancer. Canadian Urological Association Journal. Montreal: Canadian Urological Association; 2010.

Medical disclaimer

The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health.

We do our best to make sure that the information we provide is accurate and reliable but cannot guarantee that it is error-free or complete.

The Canadian Cancer Society is not responsible for the quality of the information or services provided by other organizations and mentioned on, nor do we endorse any service, product, treatment or therapy.

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