Treatments for intraocular melanoma
Melanoma of the eye most often affects structures in the uvea of the eye, including the choroid, ciliary body or iris (called intraocular melanoma). Treatment for melanoma of the eye depends on the location and size of the tumour in the eye and whether or not your vision can be saved. Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. The following are treatment options for intraocular melanoma.
Radiation therapy @(Model.HeadingTag)>
Radiation therapy is a main treatment for intraocular melanoma. It may be given as brachytherapy or external beam radiation therapy. Radiation therapy is sometimes given after surgery.
Surgery is sometimes used to treat intraocular melanoma. The types of surgery include:
- an eye resection to remove the tumour
- removal of the eyeball (called an enucleation)
- laser surgery (may be given as the main treatment or after another treatment)
- surgery to place a brachytherapy plaque over the eye tumour
- orbital exenteration to remove the eyeball, eyelid, muscles, nerves and fat if cancer has spread to the eye socket (orbit)
If intraocular melanoma spreads to the liver, surgery is sometimes used to remove the cancer in the liver (called a liver resection). Find out more about liver metastases.
Chemotherapy is sometimes used to treat advanced or recurrent intraocular melanoma that has spread to distant parts of the body (called metastatic eye cancer). It is usually given through a vein or in a pill taken by mouth and is called systemic chemotherapy.
Some doctors treat intraocular melanoma that has spread to the liver with chemotherapy delivered directly to the liver tumours through the main artery. This is done by hepatic artery infusion (also called chemoembolization).
Targeted therapy @(Model.HeadingTag)>
Targeted therapy is sometimes used to treat advanced or recurrent intraocular melanoma. Targeted therapy drugs include:
- rituximab (Rituxan)
- ibritumomab (Zevalin)
- imatinib (Gleevec)
- sorafenib (Nexavar)
The following targeted therapy drugs may be used to treat vision problems related to radiation therapy:
- bevacizumab (Avastin)
- ranibizumab (Lucentis)
If you can’t have or don’t want cancer treatment @(Model.HeadingTag)>
You may want to consider a type of care to make you feel better without treating the cancer itself. This may be because the cancer treatments don’t work anymore, they’re not likely to improve your condition or they may cause side effects that are hard to cope with. There may also be other reasons why you can’t have or don’t want cancer treatment.
Talk to your healthcare team. They can help you choose care and treatment for advanced cancer.
Clinical trials @(Model.HeadingTag)>
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Cancer Research UK. Treatment Options for Eye Cancer. Cancer Research UK; 2015: http://www.cancerresearchuk.org/about-cancer/type/eye-cancer/treatment/types/treatment-options-for-eye-cancer?view=PrinterFriendly.
Finger PT . Intraocular melanoma. DeVita VT Jr, Lawrence TS, & Rosenberg SA. Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2015: 116: 1770-1779.
Garcia-Valenzuela E. Choroidal Melanoma. 2015: http://emedicine.medscape.com/article/1190564-overview#a2.
National Cancer Institute. Intraocular (Uveal) Melanoma Treatment - for Health Professionals (PDQ®). National Cancer Institute; 2015: http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq#section/all.
National Cancer Institute. Intraocular (Uveal) Melanoma Treatment - for Patients (PDQ®). National Cancer Institute; 2015: http://www.cancer.gov/types/eye/patient/intraocular-melanoma-treatment-pdq.
Princess Margaret Cancer Centre. Princess Margaret Cancer Centre Clinical Practice Guidelines: Ocular Oncology - Uveal Melanoma. 2015: http://www.uhn.ca/PrincessMargaret/Health_Professionals/Programs_Departments/Central_Nervous_System_Eye/Documents/CPG_Ocular_%20UvealMelanoma.pdf.