Treatments for seminoma
The following are treatment options for the stages of seminoma testicular cancer. Treatment options can depend on the stage, the prognosis group (based on the International Germ Cell Cancer Consensus Group (IGCCCG) classification system) and the treatments that were used to treat the original cancer if it comes back (recurs). Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan.
Stage 1 @(Model.HeadingTag)>
Surgery is the main treatment for stage 1 seminoma. The type of surgery done is called a radical inguinal orchiectomy (an orchiectomy). This surgery removes the testicle and spermatic cord through a small opening in the groin. It’s usually done as part of the diagnosis. Surgery, followed by active surveillance, is the only treatment that most men with stage 1 seminoma need.
Active surveillance is the preferred treatment option after surgery for stage 1 seminoma because there is a low risk that the cancer will come back. It involves regular and frequent follow-up to look for signs and symptoms of recurrence. Tests done during a visit include a physical exam, blood tests to check tumour marker levels and imaging tests.
If the cancer comes back, it usually happens between 12 and 36 months after surgery. Treatment is given when you develop symptoms or the cancer changes.
Chemotherapy may be offered after surgery for stage 1 seminoma if you can’t complete the regular and frequent follow-up of active surveillance. Most men are given carboplatin (Paraplatin, Paraplatin AQ) through a needle in a vein (intravenously).
Radiation therapy may be offered after surgery for stage 1 seminoma if you can’t complete the regular and frequent follow-up of active surveillance. Radiation is directed at the lymph nodes in the back of the abdomen (called the retroperitoneum). It is sometimes given to the lymph nodes in the pelvis as well.
Stage 2 @(Model.HeadingTag)>
Surgery is part of the treatment for stage 2 seminoma. The type of surgery done is called an orchiectomy.
Radiation therapy is offered after surgery for stages 2A and some 2B seminoma. Radiation is directed at the lymph nodes in the back of the abdomen and in the pelvis.
Chemotherapy is offered after surgery for stage 2 seminoma. Chemotherapy may also be used if any cancer comes back after radiation therapy. Chemotherapy is given through a needle in a vein (intravenously). You may be offered one of the following chemotherapy combinations:
- BEP – bleomycin (Blenoxane), etoposide (Vepesid, VP-16) and cisplatin
- EP – etoposide and cisplatin
- EP is used when bleomycin affects the lungs (called pulmonary toxicity) or there is a high risk that it will cause lung damage.
Stage 3 @(Model.HeadingTag)>
Surgery is part of the treatment for stage 3 seminoma. The first type of surgery done is an orchiectomy.
Chemotherapy is a standard treatment for stage 3 seminoma. It is usually given after an orchiectomy. Chemotherapy may also be used before surgery if the cancer had already spread and doctors confirmed it was seminoma by doing a biopsy of the metastases. Chemotherapy is given through a needle in a vein. You may be offered one of the following chemotherapy combinations:
- BEP – bleomycin, etoposide and cisplatin
- VIP – etoposide, ifosfamide (Ifex) and cisplatin
- EP – etoposide and cisplatin
- EP and VIP are used when bleomycin affects the lungs or there is a high risk that it will cause lung damage.
The combination of chemotherapy drugs used depends on the tumour’s prognosis, which is based on the IGCCCG classification system.
Men who have tumours in the good prognosis group are offered BEP or EP.
Men who have tumours in the intermediate prognosis group are offered BEP or VIP.
After chemotherapy, the healthcare team will follow up with imaging tests to look for any cancer that remains (called residual disease) and signs that the cancer has come back.
If a residual lesion remains after surgery the doctors will watch the lesion for growth or changes. A
Recurrent seminoma @(Model.HeadingTag)>
Recurrent seminoma means that the cancer has come back after it has been treated. The following are treatment options for recurrent seminoma.
Chemotherapy is the main treatment for recurrent seminoma. The combination of chemotherapy drugs given will depend on the treatments that were used to treat the original cancer.
Men who were given radiation therapy after surgery to treat the cancer the first time will be offered BEP for recurrent seminoma.
Men who were given BEP or EP the first time may be given another chemotherapy drug combination (called salvage chemotherapy) through a needle in a vein. You may be offered one of the following combinations:
- VIP – etoposide, ifosfamide and cisplatin
- VeIP – vinblastine, ifosfamide and cisplatin
- TIP – paclitaxel (Taxol), ifosfamide and cisplatin
High-dose chemotherapy with carboplatin and etoposide may be used if testicular cancer comes back after it is treated with standard-dose chemotherapy. After high-dose chemotherapy, a stem cell transplant is done to replace the stem cells that are damaged or destroyed by high-dose chemotherapy. The stem cell transplant uses stem cells from your own blood (called autologous peripheral blood stem cell transplant).
Chemotherapy can also be used as palliative therapy if the cancer comes back after most other treatments. Palliative therapy is given to relieve symptoms rather than to treat the cancer itself. Palliative chemotherapy that may be used for seminoma includes:
- etoposide given by mouth (orally)
- gemcitabine (Gemzar) with oxaliplatin (Eloxatin) or paclitaxel given through a needle in a vein
Surgery may be done to remove a seminoma if it comes back and if it can be removed.
Radiation therapy can be used if the cancer comes back during active surveillance or after chemotherapy with carboplatin. The cancer must only be in the lymph nodes at the back of the abdomen. Radiation is directed at the retroperitoneal lymph nodes.
If you can’t have or don’t want cancer treatment @(Model.HeadingTag)>
You may want to consider a type of care to make you feel better without treating the cancer itself. This may be because the cancer treatments don’t work anymore, they’re not likely to improve your condition or they may cause side effects that are hard to cope with. There may also be other reasons why you can’t have or don’t want cancer treatment.
Talk to your healthcare team. They can help you choose care and treatment for advanced cancer.
Clinical trials @(Model.HeadingTag)>
Alberta Health Services. Testicular Germ Cell Tumours Clinical Practice Guideline GU-001. Version 7 ed. Alberta Health Services; 2016: https://www.albertahealthservices.ca/assets/info/hp/cancer/if-hp-cancer-guide-gu001-testicular.pdf.
American Cancer Society. Treatment Options for Testicular Cancer, by Type and Stage. 2018: https://www.cancer.org/cancer/testicular-cancer/treating/by-stage.html.
American Society of Clinical Oncology. Testicular Cancer: Treatment Options. 2017: https://www.cancer.net/cancer-types/testicular-cancer/treatment-options.
BC Cancer Agency (BCCA). Cancer Management Guidelines: Testis Pure Seminomas. 2013: http://www.bccancer.bc.ca/books/testis/management/pure-seminomas.
National Cancer Institute. Testicular Cancer Treatment (PDQ®) Health Professional Version. Bethesda, MD: National Cancer Institute; 2018: https://www.cancer.gov/types/testicular/hp/testicular-treatment-pdq.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Testicular Cancer (Version 2.2018). https://www.nccn.org/professionals/physician_gls/pdf/testicular.pdf.
Pagliaro LC and Logothetis CJ . Cancer of the testis. DeVita VT Jr, Lawrence TS, & Rosenberg SA. Cancer: Principles & Practice of Oncology. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2015: 70:988-1004.
Wood L, Kollmannsberger C, Jewett M, et al . Canadian consensus guidelines for the management of testicular germ cell cancer. Canadian Urological Association Journal. Montreal: Canadian Urological Association; 2010.
Zach E . Testicular cancer. Yarbro CH, Wujcki D, Holmes Gobel B, (eds.). Cancer Nursing: Principles and Practice. 8th ed. Burlington, MA: Jones and Bartlett Learning; 2018: 69:1955-1978.