What is penile cancer?

Last medical review:

Penile cancer starts in the cells of the penis. A cancerous (malignant) tumour is a group of cancer cells that can grow into nearby tissue and destroy it. The tumour can also spread (metastasize) to other parts of the body. Penile cancer is rare.

The penis is an external male sex organ. It’s part of the male reproductive system and urinary system. Cells in the penis sometimes change and no longer grow or behave normally. These changes may lead to non-cancerous (benign) conditions such as genital warts or balanitis xerotica obliterans (BXO, also called penile lichen sclerosus).

Changes to cells of the penis can also cause precancerous conditions. This means that the abnormal cells are not yet cancer, but there is a chance that they will become cancer if they aren’t treated. The most common precancerous condition of the penis is penile intraepithelial neoplasia (PeIN).

But in some cases, changes to penile cells can cause penile cancer. Most often, penile cancer starts in flat, thin cells called squamous cells. These cells are in the skin of the penis and the head of the penis (called the glans). This type of cancer is called squamous cell carcinoma (SCC) of the penis. SCC can develop anywhere on the penis, but it develops most often on the foreskin or the glans.

Rare types of penile cancer can also develop. These include adenocarcinoma, melanoma and basal cell carcinoma (BCC).

Diagram of the male reproductive system
Diagram of the male reproductive system

Expert review and references

  • Marie-Pier St-Laurent, MD, FRCSC
  • Brouwer OR, Albersen M, Parnham A, et al. European Association of Urology-American Society of Clinical Oncology collaborative guideline on penile cancer: 2023 update. European Urology. 2023: 83(6):548–560.
  • Engelsgjerd JS, Leslie SW, LaGrange CA. Penile cancer and penile intraepithelial neoplasia. StatPearls [Internet]. StatPearls Publishing; 2024. https://www.statpearls.com/.
  • Macmillan Cancer Support. Penile cancer. 2022. https://www.macmillan.org.uk/.
  • Mark JR, Hurwitz MD, Gomella LG, Kelly WK. Cancer of the urethra and penis. DeVita VT Jr, Lawrence TS, Rosenberg S. eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, Chapter 46, https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.

The penis

The penis is an external male sex organ. It’s part of the male reproductive system and urinary system. It contains the urethra that carries semen and urine outside of the body.

Cancerous tumours of the penis

Squamous cell carcinoma (SCC) is the most common type of penile tumour. There are also rare types of penile tumours.

Precancerous conditions of the penis

Precancerous conditions of the penis are changes to cells that make them more likely to develop into cancer.

Non-cancerous conditions of the penis

Genital warts and balanitis xerotica obliterans (BXO) are the most common non-cancerous conditions of the penis.

Your trusted source for accurate cancer information

With support from readers like you, we can continue to provide the highest quality cancer information for over 100 types of cancer.

We’re here to ensure easy access to accurate cancer information for you and the millions of people who visit this website every year. But we can’t do it alone.

Every donation helps fund reliable cancer information, compassionate support services and the most promising research. Please give today because every contribution counts. Thank you.

Medical disclaimer

The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health.

We do our best to make sure that the information we provide is accurate and reliable but cannot guarantee that it is error-free or complete.

The Canadian Cancer Society is not responsible for the quality of the information or services provided by other organizations and mentioned on cancer.ca, nor do we endorse any service, product, treatment or therapy.


1-888-939-3333 | cancer.ca | © 2026 Canadian Cancer Society