Cancerous tumours of the mouth

Last medical review:

A cancerous tumour of the mouth can grow into and destroy nearby tissue. It can also spread (metastasize) to other parts of the body. Cancerous tumours are also called malignant tumours.

Squamous cell carcinoma

The most common type of oral cancer is squamous cell carcinoma (SCC). SCC starts in the flat, thin cells (called squamous cells) that make up the oral mucosa (mucous membrane) that lines the inside of the mouth.

Rare mouth tumours

The following are other types of cancer that can start in the mouth but are very rare.

Salivary gland cancer starts in the cells of the salivary glands, which make and release saliva. Find out more about salivary gland cancer.

Melanoma is a type of skin cancer that starts in cells (called melanocytes) that make melanin, which gives skin, hair and eyes their colour. It can start anywhere in the mouth. Find out more about melanoma.

Soft tissue sarcoma starts in the cells of the body's soft tissues. It can occur in the soft tissues of the mouth. Find out more about soft tissue sarcoma.

Expert review and references

  • Patricia Brooks, HBSc, MSc, DDS, FRCD(C), Dip ABOMP, PhD
  • Mark Taylor, MD, FRCSC
  • American Cancer Society. Oral Cavity (Mouth) and Oropharyngeal (Throat) Cancer. 2021. https://www.cancer.org/.
  • Cancer Research UK. Mouth and oropharyngeal cancer. 2024. https://www.cancerresearchuk.org/.
  • Dziegielewski PT, Mendenhall WM, Dunn LA. Cancer of the Oral Cavity. DeVita VT Jr, Lawrence TS, Rosenberg S. eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, [chapter 27], https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.
  • Hashibe M, Strugis EM, Ferlay J, Winn DM. Oral Cavity, Oropharynx, Lip, and Salivary Glands. Thun MJ, Linet MS, Cerhan JR, Haiman CA, Schottenfeld D, eds.. Schottenfeld and Fraumeni Cancer Epidemiology and Prevention . 4th ed. New York, NY: Oxford University Press; 2018: Kindle version, [chapter 29] https://read.amazon.ca/?asin=B0777JYQQC&language=en-CA.
  • Tuluc M, Bar-Ad V, Cognetti D, Johnson J, Axelrod R. Uncommon Tumors of the Oral Cavity and Adjacent Structures. Raghavan D, Ahluwalia MS, Blanke CD, et al, eds.. Textbook of Uncommon Cancer . 5th ed. Hoboken, NJ: Wiley Blackwell; 2017: Kindle version, [chapter 10], https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.

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