Radiation therapy for mesothelioma

Last medical review:

Radiation therapy uses high-energy rays or particles to destroy cancer cells.

If you have advanced pleural or peritoneal mesothelioma, you may be offered radiation therapy to relieve pain or control symptoms. This is called palliative radiation therapy.

Your healthcare team will use what they know about the cancer and about your health to plan the type and amount of radiation, and when and how it is given.

External radiation therapy

During external radiation therapy, a machine directs radiation through the skin to the tumour and some of the tissue around it. External radiation therapy is also called external beam radiation therapy.

Intensity-modulated radiation therapy (IMRT) is used for mesothelioma because it can accurately target the area to be treated and spare as much normal tissue as possible. IMRT delivers radiation from many different angles to treat cancer that has spread along the mesothelium. In addition to shaping and aiming the radiation beams, IMRT allows the radiation oncologist to adjust the strength (intensity) of the individual beams. This reduces the dose of radiation reaching nearby normal tissue while allowing a higher dose to be delivered to the tumour. It is useful for treating tumours in hard-to-reach areas.

Side effects

During radiation therapy, your healthcare team protects healthy cells in the treatment area as much as possible. Side effects of radiation therapy will depend mainly on the size of the area being treated, the specific area or organs being treated, the total dose of radiation and the treatment schedule. Tell your healthcare team if you have side effects that you think are from radiation therapy. The sooner you tell them of any problems, the sooner they can suggest ways to help you deal with them.

Some common side effects of radiation therapy for mesothelioma are:

Find out more about radiation therapy

Find out more about radiation therapy and side effects of radiation therapy. To make the decisions that are right for you, ask your healthcare team questions about radiation therapy.

Expert review and references

  • John Cho, MD, PhD, FRCPC
  • American Cancer Society. Malignant Mesothelioma. 2018. https://www.cancer.org/.
  • Pass H, Carbone M, Tsao A, Rosenzweig Z. Benign and Malignant Mesothelioma. DeVita VT Jr, Lawrence TS, Rosenberg S. eds. DeVita Hellman and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Philadelphia, PA: Wolters Kluwer; 2023: Kindle version, [chapter 76], https://read.amazon.ca/?asin=B0BG3DPT4Q&language=en-CA.
  • National Comprehensive Cancer Network. NCCN Guidelines for Patients: Pleural Mesothelioma. 2022.
  • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Pleural Mesothelioma Version 1.2024. 2024.
  • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Peritoneal Mesothelioma Version 1.2024. 2024.
  • Nowak AK, Edwards JG, Creaney J. Mesothelioma. Raghavan D, Ahluwalia MS, Blanke CD, et al, eds.. Textbook of Uncommon Cancer. 5th ed. Hoboken, NJ: Wiley Blackwell; 2017: Kindle version (chapter 16) https://read.amazon.ca/?asin=B06XKD44V3&_encoding=UTF8&ref=dbs_p_ebk_r00_pbcb_rnvc00.
  • Popat S, Baas P, Faivre-Finn C, et al. Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2021: 33(2):129–142.
  • Scherpereel A, Opitz I, Berghmans T, et al. ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma. European Respiratory Journal. 2020: 55(6):1–31.

Your trusted source for accurate cancer information

With just $5 from readers like you, we can continue to provide the highest quality cancer information for over 100 types of cancer.

We’re here to ensure easy access to accurate cancer information for you and the millions of people who visit this website every year. But we can’t do it alone.

If everyone reading this gave just $5, we could achieve our goal this month to fund reliable cancer information, compassionate support services and the most promising research. Please give today because every contribution counts. Thank you.

Medical disclaimer

The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health.

We do our best to make sure that the information we provide is accurate and reliable but cannot guarantee that it is error-free or complete.

The Canadian Cancer Society is not responsible for the quality of the information or services provided by other organizations and mentioned on cancer.ca, nor do we endorse any service, product, treatment or therapy.


1-888-939-3333 | cancer.ca | © 2025 Canadian Cancer Society