Treatments for moderately advanced laryngeal cancer

Last medical review:

You may be offered the following treatments for moderately advanced (stage 3) laryngeal cancer. Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan.

Chemoradiation

Chemotherapy uses drugs to destroy cancer cells. Radiation therapy uses high-energy rays or particles to destroy cancer cells. Chemotherapy and radiation therapy given during the same time period (called chemoradiation) is a standard treatment for moderately advanced laryngeal cancer.

If you can’t tolerate chemoradiation because of the side effects or other health issues, you may have radiation therapy or chemotherapy on its own.

Find out more about radiation therapy and chemotherapy for laryngeal cancer.

Radiation therapy

Radiation therapy uses high-energy rays or particles to destroy cancer cells. Radiation therapy may be used to destroy cancer cells left behind after surgery (called adjuvant therapy).

Find out more about radiation therapy for laryngeal cancer.

Surgery

You may be offered surgery for moderately advanced laryngeal cancer.

The type of surgery you have will depend on where the cancer is in the larynx (voice box). If cancer is above the vocal cords (supraglottic carcinoma) or in the vocal cords (glottic carcinoma), surgery may include:

  • laser surgery to remove the tumour
  • laryngectomy to remove part or all of the larynx
  • surgery to remove lymph nodes in the neck

Surgery is usually not done to treat moderately advanced cancer below the vocal cords (subglottic carcinoma). In rare cases, a total laryngectomy will be offered to remove all of the larynx.

Find out more about surgery for laryngeal cancer.

Clinical trials

Talk to your doctor about clinical trials open to people with laryngeal cancer in Canada. Clinical trials look at new ways to prevent, find and treat cancer.

Find out more about clinical trials.

Expert review and references

  • Harold Lau, MD, FRCPC

Your trusted source for accurate cancer information

With support from readers like you, we can continue to provide the highest quality cancer information for over 100 types of cancer.

We’re here to ensure easy access to accurate cancer information for you and the millions of people who visit this website every year. But we can’t do it alone.

Every donation helps fund reliable cancer information, compassionate support services and the most promising research. Please give today because every contribution counts. Thank you.

Medical disclaimer

The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health.

We do our best to make sure that the information we provide is accurate and reliable but cannot guarantee that it is error-free or complete.

The Canadian Cancer Society is not responsible for the quality of the information or services provided by other organizations and mentioned on cancer.ca, nor do we endorse any service, product, treatment or therapy.


1-888-939-3333 | cancer.ca | © 2026 Canadian Cancer Society