Radiation therapy for hypopharyngeal cancer

Radiation therapy uses high-energy rays or particles to destroy cancer cells. Many people with hypopharyngeal cancer have radiation therapy. Your healthcare team will consider your personal needs to plan the type and amount of radiation, and when and how it is given. You may also receive other treatments.

Radiation therapy is often combined with chemotherapy to treat hypopharyngeal cancer. This is called chemoradiation. The 2 treatments are given during the same time period. The chemotherapy makes the radiation more effective.

Radiation therapy is given for different reasons. You may have radiation therapy or chemoradiation:

  • as the main treatment for small tumours
  • after surgery to reduce the risk that the cancer will come back (recur) (called adjuvant therapy)
  • to relieve pain or control the symptoms of advanced hypopharyngeal cancer (called palliative therapy)
  • if your overall health is too poor for surgery
  • to treat cancer that comes back after other treatments

Before treatment

Talk to your healthcare team to find out what you need to do before radiation therapy begins. They may discuss any or all of the following, depending on your personal needs.

Quitting smoking

Smoking during treatment may make radiation therapy for hypopharyngeal cancer less effective. Smoking may also make side effects from radiation therapy worse.

If you smoke, your healthcare team will talk to you about how they can help you quit before starting radiation therapy.

Visiting your dentist

It is important to have a complete dental exam before radiation therapy begins to prevent dental problems. Your dentist will determine if you need to have any dental work done before treatment can start, such as having unhealthy teeth removed. They will also develop a dental care plan for you to follow after radiation therapy.

Getting fitted for an immobilization mask

Many people have a custom immobilization mask made before external beam radiation therapy is given to the head and neck. The mask makes sure that you don’t move during treatment and that radiation is directed at exactly the same place each time. You will need to wear it during treatment planning and all radiation treatments.

Making sure your nutritional needs are met

You may have a gastrostomy tube (G-tube) placed before having radiation therapy for hypopharyngeal cancer. A G-tube is a feeding tube that is passed through the skin into the stomach. A G-tube will let foods and liquids pass directly into your stomach (called enteral feeding) when you find it too difficult to eat or drink. G-tubes can be placed using a flexible scope that goes through your mouth or nose, guided by an x-ray, or by creating a small surgical opening from your skin into your stomach.

Radiation therapy to the head and neck can make swallowing difficult and painful, so a gastrostomy tube can help make sure you will get the nutrition you need.

Find out more about tube feeding.

Checking your thyroid gland

The thyroid gland is in the area treated with radiation therapy for hypopharyngeal cancer. Radiation can cause cancer of the thyroid and it decreases the ability of the thyroid to produce thyroid hormone. The healthcare team takes special care to protect the thyroid during treatment. They will also do blood tests before, during and after radiation therapy to check how well the thyroid is working.

Protecting you against side effects

Radiation to the head and neck can cause certain side effects that make it difficult to swallow and may cause a lower quality of life. You may be given drugs called radioprotectants to protect normal tissue from the effects of radiation. Amifostine (Ethyol) is a radioprotectant that helps protect the salivary glands from the effects of radiation, which can lessen dry mouth (xerostomia).

External beam radiation therapy

During external beam radiation therapy, a machine directs radiation through the skin to the tumour and some of the tissue around it.

Hypopharyngeal cancer is usually treated with external beam radiation therapy. It may be used alone to treat stages 1 and 2 hypopharyngeal cancer. It may be used to treat lymph nodes in the neck (cervical lymph nodes). It may also be used instead of surgery if you aren’t well enough to have surgery.

External beam radiation therapy is usually given once a day for 5 days a week over a period of 5 to 7 weeks. The healthcare team will take special care to protect the surrounding tissues from the radiation as much as possible. These tissues include the salivary glands, the thyroid gland and the spinal cord.

There are different types of external beam radiation therapy that may be used to treat hypopharyngeal cancer.

3D conformal radiation therapy (3D CRT) delivers radiation to the tumour from different directions. The radiation beams are all the same strength.

Intensity-modulated radiation therapy (IMRT) uses computer-generated images to deliver radiation directly to the tumour or lymph nodes from many different angles. A higher dose can be given to the tumour while the normal tissues near the tumour get less radiation. It may be used for hypopharyngeal cancer when there is little risk that cancer cells have spread into the surrounding tissue.

Side effects

Side effects can happen with any type of treatment for hypopharyngeal cancer, but everyone’s experience is different. Some people have many side effects. Other people have few or none at all.

During radiation therapy, the healthcare team protects healthy cells in the treatment area as much as possible. But damage to healthy cells happens and causes side effects. Side effects can happen any time during, immediately after or a few days or weeks after radiation therapy. Most severe side effects do not occur until 3 to 4 weeks into therapy. Sometimes late side effects develop months or years after radiation therapy. Many side effects go away on their own or can be treated, but some side effects are permanent.

Side effects of radiation therapy will depend mainly on the size of the area being treated, the specific area or organs being treated, the total dose of radiation, whether chemotherapy is given at the same time (chemoradiation) and the treatment schedule. Chemotherapy makes the radiation more effective in killing cancer cells, but it also makes the side effects from radiation worse.

Some common side effects of radiation therapy used for hypopharyngeal cancer are:

Tell your healthcare team if you have these side effects or others you think might be from radiation therapy. The sooner you tell them of any problems, the sooner they can suggest ways to help you deal with them.

Questions to ask about radiation therapy

Find out more about radiation therapy and side effects of radiation therapy. To make the decisions that are right for you, ask your healthcare team questions about radiation therapy.

Expert review and references

  • American Cancer Society. Laryngeal and Hypopharyngeal Cancers. 2014: https://www.cancer.org/.
  • Hamoir M, Machiels JP, Schmitz S, Gregoire V . Multidisciplinary management of hypopharyngeal carcinoma. Bernier J (ed.). Head and Neck Cancer: Multimodality Management. Springer; 2016: 28: 511-537.
  • Harry Quon . Hypopharyngeal Cancer . 2017 : https://www.medscape.com/oncology.
  • Kruser TJ, Pagedar NA, Hoffman HT, Harari PM . Cancers of the hypopharynx and cervical esophagus: general principles and management. Harrison LB, Sessions RB, Kies MS (eds.). Head and Neck Cancer: A Multidisciplinary Approach. 4th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2014: 19: 482 - 509.
  • Mendenhall WM, Werning JW, Pfister DG . Cancer of the head and neck. DeVita VT Jr, Lawrence TS, & Rosenberg SA. Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2015: 38: 422-473.
  • Mourad WF, Hu KS, Choi WH, et al . Cancer of the oropharynx: General principles and management. Harrison LB, Sessions RB, Kies MS (eds.). Head and Neck Cancer: A Multidisciplinary Approach. 4th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2014: 17A: 373 - 414.