Treatments for melanoma of unknown primary

Last medical review:

Melanoma is a type of cancer that starts in melanocyte cells of the skin. Melanocytes make melanin. Melanin gives skin, hair and eyes their colour.

Melanoma of unknown primary is usually found in lymph nodes.

Surgery to remove the lymph nodes is called a lymph node dissection.. It is the main treatment for melanoma of unknown primary.

Find out more about a lymph node dissection.

Clinical trials

Talk to your doctor about clinical trials open to people with CUP in Canada. Clinical trials look at new ways to prevent, find and treat cancer. Find out more about clinical trials.

If you can’t have or don’t want cancer treatment

You may want to consider a type of care to make you feel better without treating the cancer itself. This may be because the cancer treatments don't work anymore, they're not likely to improve your condition or they may cause side effects that are hard to cope with. There may also be other reasons why you can't have or don't want cancer treatment.

Talk to your healthcare team. They can help you choose care and treatment for advanced cancer.

Expert review and references

  • Tien Le , MD, FRCSC, DABOG
  • American Cancer Society . Treating a Cancer of Unknown Primary . 2018 : https://www.cancer.org/.
  • PDQ Adult Treatment Editorial Board. Carcinoma of Unknown Primary Treatment (PDQ®) – Health Professional Version. Bethesda, MD: National Cancer Institute; 2018: https://www.cancer.gov/.
  • PDQ Adult Treatment Editorial Board. Carcinoma of Unknown Primary Treatment (PDQ®) – Patient Version. Bethesda, MD: National Cancer Institute; 2021: https://www.cancer.gov/.
  • Tan WW . Medscape Reference: Metastatic Cancer With Unknown Primary Site . 2022 : https://www.medscape.com/oncology.

Medical disclaimer

The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health.

We do our best to make sure that the information we provide is accurate and reliable but cannot guarantee that it is error-free or complete.

The Canadian Cancer Society is not responsible for the quality of the information or services provided by other organizations and mentioned on cancer.ca, nor do we endorse any service, product, treatment or therapy.


1-888-939-3333 | cancer.ca | © 2024 Canadian Cancer Society