A vaccine stimulates the immune system to produce antibodies to fight a disease.
Most vaccines help protect us from infections, such as measles or polio. They are made from weakened or killed germs that do not cause the infection but cause the immune system to make
Cancer treatment vaccines are different because they try to get the immune system to attack cancer cells that are already in the body. Most cancer treatment vaccines are still being studied in clinical trials.
Vaccines to prevent cancer @(Model.HeadingTag)>
Preventive (prophylactic) vaccines are used to prevent viral infections that cause cancer or contribute to cancer development. They are designed to stimulate the immune system to attack certain viruses before they cause an infection. These vaccines are given to healthy people before cancer develops.
Human papillomavirus (HPV) vaccines protect against infection caused by certain types of HPV. The 3 HPV vaccines available in Canada are Gardasil, Cervarix and Gardasil 9. These vaccines help protect against infection with types of HPV most commonly linked with precancerous conditions and cervical cancer. Gardasil 9 also protects against other types of HPV that can cause cancer.
Currently, HPV vaccines are approved in Canada to prevent cervical cancer related to HPV. This virus is also associated with vaginal, vulvar, anal, penile and some oral cavity and throat (pharyngeal) cancers.
Hepatitis B vaccines may lower the risk of developing liver cancer in some people. Hepatitis is inflammation of the liver that can be caused by certain viruses. People with long-term infection with the hepatitis B virus (HBV) are at a higher risk of liver cancer.
Vaccines to treat cancer @(Model.HeadingTag)>
Cancer treatment vaccines can be made up of cancer cells, parts of cancer cells or
The following cancer treatment vaccines are most commonly studied.
Whole tumour vaccines use the whole cancer cell, not just an antigen, to make the vaccine. The vaccine is made from your own cancer cells, cancer cells from another person or cancer cells grown in a lab.
Antigen vaccines are made from antigens in cancer cells. The goal is to stimulate the immune system to attack the cancer.
Dendritic cell vaccines are made from
DNA vaccines are made with bits of DNA from cancer cells. The vaccine should make the cells of the immune system better at reacting to and destroying cancer cells.
Anti-idiotype vaccines stimulate the body to produce antibodies against cancer cells almost in the same way as antigen vaccines. An idiotype is the part of an antibody that determines the specific antigen the antibody will act against.
Side effects of cancer vaccines @(Model.HeadingTag)>
Side effects can happen with any type of treatment, but everyone’s experience is different. Some people have many side effects. Other people have few or none at all.
Side effects of cancer vaccines will depend mainly on the type of vaccine and usually last for only a short time. Tell your healthcare team if you have these side effects or others you think might be from cancer vaccines. The sooner you tell them of any problems, the sooner they can suggest ways to help you deal with them.
The most common side effects that people tend to experience with cancer vaccines are:
American Cancer Society. Cancer Vaccines. 2015: https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/cancer-vaccines.html.
Cancer Research UK. Vaccines to Treat Cancer. Cancer Research UK; 2017: http://about-cancer.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/immunotherapy/types/vaccines-to-treat-cancer.
Muehbauer PM, Callahan A, Zlott D, Dahl BJ . Biotherapy. Yarbro CH, Wujcki D, Holmes Gobel B, (eds.). Cancer Nursing: Principles and Practice. 8th ed. Burlington, MA: Jones and Bartlett Learning; 2018: 19: 611 - 651.
National Cancer Institute. Cancer Vaccines. 2015: https://www.cancer.gov/about-cancer/causes-prevention/vaccines-fact-sheet.
Rosenberg SA, Robbins PF, Phan GQ, Feldman SA, Kochenderfer JN . Cancer Immunotherapy. DeVita VT Jr, Lawrence TS, Rosenberg SA. Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2015: 14: 158 - 173.