If oropharyngeal cancer spreads

Cancer cells can spread from the oropharynx to other parts of the body. This spread is called metastasis.

Understanding how a type of cancer usually grows and spreads helps your healthcare team plan your treatment and future care. If oropharyngeal cancer spreads, it can spread to the following:

  • lymph nodes in the neck (cervical lymph nodes)
  • the pharyngeal wall
  • muscles in the wall of the pharynx (throat)
  • jaw and tongue muscles
  • the jawbones
  • cranial nerves
  • the hard and soft palates
  • blood vessels in the neck
  • the nasopharynx
  • the hypopharynx
  • the larynx (voice box)
  • the base of the skull
  • the lung
  • the liver
  • the bone

People with oropharyngeal cancer have a higher risk of developing a second type of cancer in nearby organs such as the esophagus, larynx or lungs. The second type of cancer may be found at the same time as oropharyngeal cancer or after oropharyngeal cancer is diagnosed.

Expert review and references

  • American Cancer Society. Oral Cavity and Oropharyngeal Cancer. 2014. https://www.cancer.org/.
  • Mendenhall WM, Werning JW, Pfister DG. Cancer of the head and neck. DeVita VT Jr, Lawrence TS, & Rosenberg SA. Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2015: 38: 422-473.
  • Mourad WF, Hu KS, Choi WH, et al. Cancer of the oropharynx: General principles and management. Harrison LB, Sessions RB, Kies MS (eds.). Head and Neck Cancer: A Multidisciplinary Approach. 4th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2014: 17A: 373 - 414.
  • National Cancer Institute. Oropharyngeal Cancer Treatment (PDQ®) Health Professional Version. 2017. https://www.cancer.gov/.

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