Disease progression of chronic lymphocytic leukemia
Cancer cells can spread from where they start to other parts of the body. Unlike other types of cancer, leukemia does not usually form solid tumours in other organs in the body. Leukemia is a cancer of the blood-forming tissue in the bone marrow, and it can develop wherever the blood travels. As a result, chronic lymphocytic leukemia (CLL) is often widespread when it is found.
Understanding how a type of cancer usually progresses helps your healthcare team plan your treatment and future care. Leukemia cells usually collect in the lymph nodes, spleen and liver. The buildup of leukemia cells in these organs affects them so they don’t work normally.
Symptoms of the progression of CLL include:
- more than 10% weight loss in 6 months
- extreme fatigue
- fever for more than 2 weeks without any signs of infection
- night sweats for longer than 1 month
- an increasing number of CLL cells in the bone marrow that make the bone marrow not work properly, leading to anemia (lower numbers of healthy red blood cells) or thrombocytopenia (lower number of platelets in the blood)
- a spleen that is larger than normal and may be causing symptoms such as discomfort or a feeling of fullness
- more areas of enlarged lymph nodes in the body that cause discomfort
- an enlarged liver that causes discomfort
- the number of lymphocytes increases by more than 50% in 2 months or doubles in less than 6 months (rapid doubling time)
In rare cases, CLL develops into a high-grade non-Hodgkin lymphoma. This condition is called Richter transformation, and if this happens, it usually develops into a diffuse large B-cell lymphoma, which is treated like a lymphoma.
Your trusted source for accurate cancer information
With just $5 from readers like you, we can continue to provide the highest quality cancer information for over 100 types of cancer.
We’re here to ensure easy access to accurate cancer information for you and the millions of people who visit this website every year. But we can’t do it alone.
If everyone reading this gave just $5, we could achieve our goal this month to fund reliable cancer information, compassionate support services and the most promising research. Please give today because every contribution counts. Thank you.