Liver problems

Liver problems can develop after some types of cancer treatment. Sometimes liver problems happen as a late effect of treatments for cancer during childhood. Liver problems often develop slowly and progress gradually over time.

How the liver works

The liver is part of the digestive system. It is under the ribcage in the upper-right part of the abdomen. The liver makes enzymes and bile to help digest food. It also makes proteins that help the blood clot. The liver cleans the blood by removing harmful materials including chemotherapy drugs and other medicines.

Diagram of the location of the liver
Diagram of the location of the liver


Treatments for cancer, including certain types of chemotherapy, radiation therapy, immunotherapy and stem cell transplants, can cause liver problems.


Some chemotherapy drugs known to cause liver damage are:

  • mercaptopurine (Purinethol)
  • thioguanine (Lanvis)
  • asparaginase (Kidrolase)
  • carmustine (BiCNU, BCNU)
  • cytarabine (Cytosar)
  • methotrexate
  • cisplatin
  • cyclophosphamide (Procytox)

Radiation therapy

Receiving high doses of radiation to the abdomen, pelvis, spine or whole body (called total body irradiation, or TBI) can cause liver damage.


Some immunotherapy drugs, such as pembrolizumab (Keytruda), ipilimumab (Yervoy) and nivolumab (Opdivo), can cause liver damage.

Stem cell transplant

High-dose chemotherapy and total body irradiation given to prepare for a stem cell transplant can cause liver damage. Chronic graft-versus-host disease (GVHD) or veno-occlusive disease (VOD) of the liver that develops after a stem cell transplant can also cause liver damage.

Other factors

Other factors that can increase the risk of liver problems include:

  • a tumour in the liver
  • surgery to remove a large part of the liver
  • having other conditions that affect the liver such as hepatitis
  • drinking large amounts of alcohol
  • having many blood transfusions

Types of liver problems

Types of liver problems that can develop following some types of cancer treatment include:

  • an increase in liver enzymes with no symptoms
  • an increased risk of gallstones
  • an enlarged liver
  • hepatitis B and C (inflammation of the liver)
  • nodules in the liver
  • scarring of the liver (cirrhosis)
  • hardening of the liver (fibrosis)
  • too much iron buildup in the body from having many blood transfusions


Symptoms of liver damage can vary depending on the type of problem. Sometimes liver damage doesn’t cause any symptoms. The problem may only be identified by diagnostic tests.

Symptoms of liver problems include:

  • jaundice, which is yellowing of the skin and whites of the eyes
  • dark urine
  • pale, clay-coloured stools
  • severe itching
  • easy bruising or bleeding
  • chronic fatigue
  • pain in the abdomen
  • malaise, which is a general feeling of discomfort or illness
  • nausea
  • loss of appetite
  • an enlarged liver
  • ascites, which is a buildup of fluid in the abdomen

If symptoms get worse or don’t go away, report them to your doctor or healthcare team without waiting for your next scheduled appointment.


Before treatment for cancer begins, the healthcare team may do tests to check your liver and make sure there are no major problems. Tests may also be done during and after treatments to make sure nothing has changed.

Blood tests are done to:

  • measure levels of enzymes that are normally present in liver cells and check how well the liver is working
  • check for hepatitis
  • measure blood clotting factors
  • check for too much iron in the blood

Find out more about tests and procedures.

Preventing and managing liver problems

To prevent liver damage, the healthcare team carefully monitors people who are at risk. They use tests to check the liver in people receiving cancer treatment that can affect the liver. If they think the liver might be damaged, they may lower the dose of the drug or radiation or stop the treatment entirely to prevent further damage.

If you are at risk of liver damage following cancer treatment, you can help lower the risk by keeping your liver healthy.

  • Get immunized against hepatitis A and B.
  • Avoid alcohol or limit the amount you drink.
  • Drink plenty of water.
  • Eat a well-balanced diet and less fatty, salty, smoked and cured foods.
  • Don’t take unnecessary medicines or more than the recommended doses of medicines.
  • Don’t use illegal drugs.
  • Don’t mix drugs and alcohol.
  • Check with your doctor before taking any new over-the-counter medicines, herbs or supplements.
  • Use barrier protection (such as condoms) during sexual contact to prevent infection by viruses that can damage the liver.
  • Avoid being around chemicals that can be harmful to the liver such as solvents, aerosol cleaners, insecticides and paint thinners. Wear a mask and gloves and work in a well-ventilated area when you are around chemicals.


All people who are treated for cancer need regular follow-up. The healthcare team will develop a follow-up plan based on the type of cancer, how it was treated and your needs.

Make sure you tell your doctor all the treatments you received. If you are at risk for liver problems, you will have a physical exam each year to check for enlargement of the liver and blood tests to check liver function.

Expert review and references

  • Camp-Sorrell D . Chemotherapy toxicities and management. Yarbro CH, Wujcki D, Holmes Gobel B, (eds.). Cancer Nursing: Principles and Practice. 8th ed. Burlington, MA: Jones and Bartlett Learning; 2018: 16: 497 - 554.
  • Children's Oncology Group. Liver Health.
  • Landier w, Armenian SH, Meadows AT, Bhatia S . Late effects of childhood cancer and its treatment. Pizzo PA & Poplack DG (eds.). Principles and Practice of Pediatric Oncology. 7th ed. Philadelphia: Wolters Kluwer; 2016: 48: 1173 - 1196.
  • Martini FH, Timmons MJ, Tallitsch RB. Human Anatomy. 7th ed. San Francisco: Pearson Benjamin Cummings; 2012.
  • National Cancer Institute. Late Effects of Treatment for Childhood Cancer (PDQ®) Health Professional Version. 2018:

Medical disclaimer

The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health.

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