Treatments for stage 3 and stage 4A vaginal cancer

Last medical review:

You may be offered the following treatments for stage 3 and stage 4A vaginal cancer. Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan.

Radiation therapy or chemoradiation

Radiation therapy uses high-energy rays or particles to destroy cancer cells. It is usually used to treat stage 3 and 4A vaginal cancer. External radiation therapy and brachytherapy may be used together.

Chemoradiation may be used instead of radiation therapy alone to treat vaginal cancer. The most common chemotherapy drug given during radiation therapy is cisplatin, but other chemotherapy drugs may also be used.

Find out more about radiation therapy for vaginal cancer.

Chemotherapy

Chemotherapy uses drugs to destroy cancer cells. It may be used along with radiation therapy to treat stage 3 and stage 4A vaginal cancer. The chemotherapy can help make the radiation therapy work better.

Find out more about chemotherapy for vaginal cancer.

Clinical trials

Talk to your doctor about clinical trials open to people with vaginal cancer in Canada. Clinical trials look at new ways to prevent, find and treat cancer. Find out more about clinical trials.

If you can’t have or don’t want cancer treatment

You may want to consider a type of care to make you feel better without treating the cancer itself. This may be because the cancer treatments don't work anymore, they're not likely to improve your condition or they may cause side effects that are hard to cope with. There may also be other reasons why you can't have or don't want cancer treatment.

Talk to your healthcare team. They can help you choose care and treatment for advanced cancer.

Expert review and references

  • Tien Le , MD, FRCSC, DABOG
  • Jhingran A . Updates in the treatment of vaginal cancer. International Journal of Gynecological Cancer. BMJ; 2022: 32:344-351.
  • Jewell EL. Vaginal Cancer Treatment Protocols . eMedicine/Medscape; 2021: https://emedicine.medscape.com/.
  • PDQ® Adult Treatment Editorial Board. Vaginal Cancer Treatment Overview(PDQ®)–Patient Version. Bethesda, MD: National Cancer Institute; 2022: https://www.cancer.gov/.
  • PDQ® Adult Treatment Editorial Board. Vaginal Cancer Treatment Overview (PDQ®)–Health Professional Version . Bethesda, MD: National Cancer Institute; 2022: https://www.cancer.gov/.
  • American Cancer Society. Treating Vaginal Cancer . 2018: https://www.cancer.org/.
  • British Columbia Cancer Agency. Vaginal Cancer. 2021: http://www.bccancer.bc.ca/.
  • American Society of Clinical Oncology (ASCO) . Cancer.net: Vaginal Cancer . 2021 .

Medical disclaimer

The information that the Canadian Cancer Society provides does not replace your relationship with your doctor. The information is for your general use, so be sure to talk to a qualified healthcare professional before making medical decisions or if you have questions about your health.

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