Conditions related to multiple myeloma

There are several conditions related to multiple myeloma. Some conditions may occur in people diagnosed with multiple myeloma. Other conditions don’t develop in people with multiple myeloma but these conditions have some similar features as multiple myeloma.

Osteosclerotic myeloma (POEMS syndrome) is a rare disorder that affects multiple systems of the body. The name POEMS syndrome comes from the most common features of the disease:

Peripheral neuropathy causes weakness, loss of sensation, pins and needles or burning pain in the hands and feet. It is usually the worst symptom of POEMS syndrome.

Organomegaly refers to organ enlargement. People with POEMS syndrome often have larger than normal liver, spleen and lymph nodes.

Endocrinopathy is a term used to describe the endocrine system when it isn’t working right. The endocrine system is the group of hormone-producing glands and tissues that help regulate growth, sexual development and other body functions.

M-proteins are found in the blood and urine. There may also be plasma cell tumours, called plasmacytomas.

Skin changes might include skin darkening, thickening or tightening. Other changes may include hair growth on the face, limbs and chest, swelling (edema) of the legs and feet, and whitening of the nails.

Treatment options for osteosclerotic myeloma include:

• radiation therapy
• chemotherapy
• stem cell transplant
• targeted therapy
• hormone replacement therapy (for those whose endocrine organs are affected)

People with Waldenstrom macroglobulinemia often have a high amount of immunoglobulin M (IgM) or M-protein in the blood. This can cause a condition called hyperviscosity syndrome. People with hyperviscosity syndrome have thicker blood than normal and can have bleeding problems, vision problems and nervous system problems.

Waldenstrom macroglobulinemia is also related to an indolent (slow-growing) type of B-cell non-Hodgkin lymphoma (NHL). It can also be called lymphoplasmacytic lymphoma.

Treatment options for Waldenstrom macroglobulinemia include:

• watchful waiting (used only if you don’t have symptoms)
• targeted therapy
• chemotherapy
• plasma exchange (a machine removes plasma and IgM from the blood when it is too thick)
• stem cell transplant

Find out more about Waldenstrom macroglobulinemia.

Amyloid refers to a protein or part of a protein that forms abnormal clumps in the body. In light chain amyloidosis, the light chains of an immunoglobulin build up in tissues of the body (called amyloid deposits). Amyloid can build up in any tissue and interfere with its function. Light chain amyloidosis affects about 10% to 15% of people with multiple myeloma but it can also develop in people who don’t have the disease. It may also be associated with other B-cell cancers, such as lymphoma and chronic lymphocytic leukemia( CLL).

Amyloid is sometimes seen on a bone marrow biopsy sample, but a doctor may need to biopsy other tissues, such as the fat on the abdomen (belly), to look for amyloid. In rare cases, a doctor will biopsy the heart or kidneys to look for amyloid if a person is having heart or kidney problems.

Treatment for amyloidosis is like treatment for multiple myeloma. It targets the abnormal plasma cells. Treatment options include:

• chemotherapy
• radiation therapy
• targeted therapy
• stem cell transplant

Plasma cell leukemia (PCL) is a rare, aggressive condition where large numbers of plasma cells circulate in the blood. The circulating plasma cells may be the first evidence of disease (called primary PCL) or may develop in the later stages of multiple myeloma (called secondary PCL). Most cases of PCL are primary PCL. PCL is more aggressive than multiple myeloma.

You may be offered chemotherapy or a stem cell transplant or both to treat PCL.

Heavy chain disease is a rare disease of B cells (also called B lymphocytes). In heavy chain disease, plasma cells make incomplete immunoglobulin molecules that only have the heavy chain part of the immunoglobulin. There are 3 types of heavy chain disease, which are classified according to the type of heavy chain.

Find out more about immunoglobulins.

Heavy chains of IgA are found in IgA heavy chain disease (also called alpha heavy chain disease). IgA is the most common type of heavy chain disease, and it affects the gastrointestinal tract. Experts believe it is caused by long-term stimulation of the immune system by bacteria. Treatment options for IgA heavy chain disease include chemotherapy and antibiotics with or without corticosteroids.

Heavy chains of IgG are found in IgG heavy chain disease. IgG heavy chain disease is a type of lymphoproliferative disorder where lymphocytes are made in high amounts. Some people have a mild form of the disease while others have an aggressive form. Treatment options for IgG heavy chain disease include watchful waiting for those with a mild form of the disease, radiation therapy and chemotherapy.

IgM heavy chain disease sometimes occurs in people with chronic lymphocytic leukemia (CLL). Some people have a mild form of the disease while others have an aggressive form. Treatment options for IgM heavy chain disease include watchful waiting and chemotherapy.