Dental problems can develop during and after some types of cancer treatment. Sometimes dental problems happen as a late effect of treatments for cancer during childhood. Children younger than 8 years of age during treatment have a higher risk of having dental problems because the teeth aren't fully developed yet.
The following cancer treatments can cause dental problems.
Radiation therapy @(Model.HeadingTag)>
Radiation therapy to the mouth, head or neck can affect the lining of the mouth and the salivary glands, which are very sensitive to radiation. This can cause dry mouth, tooth decay and other dental problems. The higher the dose of radiation, the greater the risk of dental problems.
If chemotherapy drugs are given along with radiation therapy, there is a greater risk for dental problems.
Total body irradiation (TBI) can affect the teeth. In children, the teeth may not develop normally. In adults, TBI may cause dental problems.
Chemotherapy can affect the lining of the mouth and the salivary glands, which can cause dry mouth, tooth decay and other dental problems. Children who are younger than 8 years of age or whose adult teeth haven't developed yet can also have problems with tooth development after chemotherapy. Dental problems are more common when higher doses of chemotherapy are given.
Stem cell transplant @(Model.HeadingTag)>
Different aspects of a stem cell transplant can lead to dental problems. Drugs that are given to make sure that the body doesn't reject the new stem cells, such as azathioprine (Imuran), increase the risk for dental problems. Chemotherapy drugs commonly used in preparing for a stem cell transplant, such as busulfan and cyclophosphamide, can also affect the teeth and how they develop. People who develop chronic graft-versus-host disease (GVHD) from a stem cell transplant may also develop dental problems, such as cavities and gum disease.
Types of dental problems @(Model.HeadingTag)>
Different types of dental problems can develop after chemotherapy, radiation therapy or a stem cell transplant, including:
- increased risk of cavities
- shortening or thinning of teeth roots
- absence of teeth or roots
- white or discoloured patches on the teeth
- grooves or pits in the teeth
- easy staining of the teeth
- taste changes
Radiation therapy to the mouth or jaw area can also cause:
- dry mouth due to lowered saliva production
- greater risk that the teeth will be sensitive to hot and cold
- trismus (difficulty opening the jaw)
- temporomandibular joint (TMJ) dysfunction, which causes pain in front of the ears
- hardening of the jaw muscles (called fibrosis)
- gum disease
- osteoradionecrosis (bone death caused by radiation therapy)
- oral cancer
Children who are treated before their teeth are fully developed may also have the following problems with the development of the teeth and jaw:
- small teeth
- permanent teeth that come in later than usual (called delayed eruption)
- early loss of teeth or baby teeth that don't fall out
- overbite or underbite
- abnormal growth of bones in the face and neck
Symptoms can vary depending on the type of dental problem and can include:
- red, tender or puffy gums
- gums that bleed easily
- tooth pain or sensitivity
- a sore in the mouth that doesn't heal or bleeds easily
- a change in the colour of the tissues in the mouth
- a lump, thickening or rough spot in the mouth
- soreness or numbness in the mouth or on the lips
You may see a dentist, an orthodontist or an oral surgeon to check for dental problems. They may do the following tests:
- examining the teeth and mouth
- x-rays to assess tooth and jaw development
- a panorex x-ray (an x-ray of the upper and lower jaw) to show the health of the teeth, roots and supporting bones
Managing dental problems @(Model.HeadingTag)>
Treatments will depend on the types of dental problems that develop and can include:
- caps or crowns for adult teeth that are unhealthy or don't develop normally
- reconstructive surgery to correct poor bone growth of the face or jaw
- stretching exercises for the jaw to improve your ability to open your mouth
- bonding (a thin coating of plastic material) applied to the surface of the teeth to improve the appearance of crooked or small teeth
If you had high doses of radiation to the face or mouth, your dentist will talk to you and the radiation oncologist about the risk of osteoradionecrosis before doing any dental surgery.
Preventing dental problems @(Model.HeadingTag)>
Taking care of your teeth and gums is always important. Dental care is very important if you received radiation therapy or chemotherapy, especially if at a young age.
Talk to your dentist about how you can keep your teeth and mouth as healthy as possible. Your dentist may recommend the following:
- Have regular follow-ups with your dentist.
- Brush your teeth at least 2 times each day. Floss your teeth 1 to 2 times each day. Use a fluoride rinse or gel each day.
- Use antibacterial, alcohol-free fluoride rinses.
- Apply fluoride as directed by your dentist.
- Drink liquids often.
- Use artificial saliva.
- Limit sweets and carbohydrate-rich foods.
- Don't use tobacco products.
- Limit the amount of alcohol you drink.
All people who are treated for cancer need regular follow-up. The healthcare team will develop a follow-up plan based on the type of cancer, how it was treated and your needs.
People who receive radiation therapy to the head or neck area or a stem cell transplant should get dental checkups every 6 months. Make sure you tell your dentist about all the treatments you received.
Follow-up may include the following:
- examining the teeth and gums
- dental x-rays
- examining the mouth for signs of oral cavity cancer
Mary Stuart, FNP, MSN, MN
Late effects of childhood cancer. American Society of Clinical Oncology (ASCO). Cancer.Net. Alexandria, VA.: American Society of Clinical Oncology (ASCO); 2011.
Children's Oncology Group. Dental Health. https://www.childrensoncologygroup.org/index.php/sensory/dentalhealth?tmpl=component&print=1. Monday, January 18, 2021.
American Society of Clinical Oncology. Dental and Oral Health. 2019: https://www.cancer.net/coping-with-cancer/physical-emotional-and-social-effects-cancer/managing-physical-side-effects/dental-and-oral-health.
Curesearch. Dental Health After Childhood Cancer. https://curesearch.org/Dental-Health-Summary#. Monday, January 18, 2021.
Gawade PL, Hudson MM, Kaste SC, et al. A systematic review of dental late effects in survivors of childhood cancer. Pediatric Blood Cancer. 2014: 61(3): 407–416. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281834/pdf/nihms-650139.pdf.
Martini FH, Timmons MJ, Tallitsch RB. Human Anatomy. 7th ed. San Francisco: Pearson Benjamin Cummings; 2012.
Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers. National Childhood Cancer Foundation & Children's Oncology Group. CureSearch. Bethesda, MD: 2008: http://www.survivorshipguidelines.org/.