A type of therapy that uses both psoralen (P) and ultraviolet A (UVA) radiation.

The drug psoralen is given to make the skin sensitive to UVA. The skin is exposed to UVA 1–2 hours later. The light works to activate the drug, which interferes with cancer cells’ DNA and causes them to die.

PUVA is used to treat common skin conditions (such as psoriasis, vitiligo and eczema) and skin cancers.