Research in uterine cancer
We are always learning more about cancer. Researchers and healthcare professionals use what they learn from research studies to develop better ways to treat uterine cancer. The following is a selection of research showing promise for treating uterine cancer, especially endometrial carcinoma (the most common type of uterine cancer).
We’ve included information from the following sources. Each item has an identity number that links to a brief overview (sometimes called an abstract).
- PubMed, US National Library of Medicine (PMID)
- Canadian Cancer Trials and ClinicalTrials.gov (NCT)
Chemotherapy and radiation therapy @(Model.HeadingTag)>
The following is noteworthy research in chemotherapy and radiation therapy for uterine cancer.
Chemoradiation is a treatment that gives chemotherapy with radiation therapy during the same time period. A phase 3 clinical trial called PORTEC-3 studied how well chemoradiation works compared to radiation therapy alone for high-risk endometrial carcinoma. Researchers found that chemoradiation improved overall
Intensity-modulated radiation therapy (IMRT) is an advanced way of giving radiation therapy that shapes the radiation beams to give different doses to different parts of the treatment area. IMRT may be the best way to give radiation to the pelvis after surgery for uterine cancer. Research shows that IMRT causes fewer
Proton therapy uses proton beams (positively charged particles) instead of x-ray beams to treat cancer. Protons cause less damage to tissues they pass through before reaching their target. Researchers are studying proton therapy as a treatment option in a small number of women with endometrial carcinoma or cervical cancer (ClinicalTrials.gov, NCT 03184350; Radiation Oncology, PMID 29179751).
Vaginal brachytherapy is a type of radiation therapy in which a
Targeted therapy @(Model.HeadingTag)>
Targeted therapy uses drugs to target specific molecules (such as proteins) on cancer cells or inside them. These molecules help send signals that tell cells to grow or divide. By targeting these molecules, the drugs stop the growth and spread of cancer cells and limit harm to normal cells.
Researchers are studying different targeted therapy drugs to see how well they work to treat uterine cancer, especially when it has spread to other parts of the body (advanced or metastatic uterine cancer). Some of the targeted therapy drugs that researchers are studying include:
- ridaforolimus (Critical Reviews in Oncology/Hematology, PMID 27931828; Canadian Cancer Trials, NCT 00739830)
- cediranib and olaparib (Lynparza) (Canadian Cancer Trials, NCT 02502266)
- perifosine (Investigational New Drugs, PMID 28864978)
- palbociclib (Ibrance) for uterine leiomyosarcoma (Oncologist, PMID 28283584)
Immunotherapy helps strengthen or restore the immune system’s ability to find and destroy cancer cells. Researchers are looking at a type of immunotherapy called an immune checkpoint inhibitor. The immune system normally stops itself from attacking normal cells in the body by using specific proteins called checkpoints, which are made by some immune system cells. Cancer cells sometimes use these checkpoints to avoid being attacked by the immune system. Immune checkpoint inhibitors block the checkpoint proteins so immune system cells (called T cells) can attack and kill the cancer cells.
Researchers are studying the immune checkpoint inhibitor pembrolizumab (Keytruda) to see if it can improve survival in women with advanced endometrial carcinoma (Canadian Cancer Trials, NCT 03517449).
Learn more about cancer research @(Model.HeadingTag)>
Researchers continue to try to find out more about cancer. Clinical trials are research studies that test new ways to treat cancer. They also look at ways to prevent, find and manage cancer.
Clinical trials provide information about the safety and effectiveness of new approaches to see if they should become widely available. Most of the standard treatments for cancer were first shown to be effective through clinical trials.
Find out more about clinical trials.